SSPF PUBLICATIONS

1.Shen, L.N., Liu, H., Naismith, J.H. & Hay, R.T.(2005) Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 24, 1341-1351

2.Beis, K., Srikannathasan, V., Liu, H., Fullerton, S.W.B., Bamford, V.A., Sanders, D.A.R., Chris Whitfield, C., McNeil, M.R. & Naismith, J.H. (2005) Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J. Mol. Biol., 348, 971-82

3.Williams GJ, Breazeale SD, Raetz CR & Naismith JH. (2005) Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. J Biol Chem. 280, 23000-23008

4.Dong C., Flecks S., Unversucht S., Haupt C., Van Pee, K-H., & Naismith J.H. (2005) The structure of tryptophan 7-halogenase (PrnA) suggests a mechanism for regioselective chlorination.. Science, 309, 2216-2219

5.C. Jelinska, M.J. Conroy, J.C. Craven, A. Hounslow, P.A. Bullough, J.P. Waltho, G.L. Taylor and M. F. White (2005) Obligate heterodimerisation of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging Structure, 13, 963-971.

6.A. Ariza, D.J. Richard, M.F. White and C.S. Bond. (2005) Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA. Nucleic Acids Res. 33(5) 1465-1473.

7.Fox AH, Bond CS, Lamond AI., 'P54nrb Forms a Heterodimer with PSP1 That Localizes to Paraspeckles in a RNA-dependent Manner'. (2005) Mol. Biol. Cell. In press.

8.Ariza A, Richard DJ, White MF, Bond CS. 'Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA'. (2005) Nucleic Acids Res. 33(5):1465-73

9.A. Ariza, T. J. Vickers, N. Greig, A. H. Fairlamb and C. S. Bond, 'Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I' (2005) Acta Cryst. F61, 769-772

10.Newstead, S., Watson, J.N., Knoll, T.L., Bennet, A.J. and Taylor, G.L. (2005) Biochemistry 44, 9117-9122. Structure and mechanism of action of an inverting mutant sialidase.

11.Watson, J.N., Newstead, S., Narine, A., Taylor, G. and Bennet, A.J. (2005) ChemBioChem (in press) Two nucleophilic mutants of the Micromonospora viridifaciens sialidase operate with retention of configuration via two different mechanisms

12.Newstead, S., Watson, J., Bennet, A. and Taylor. G. (2005) Acta Cryst. D. (in press) Galactose recognition by the carbohydrate-binding module of a bacterial sialidase

13.Ryan, C., Zaitsev, V., Tindal, D.J., Dyason, J.C., Thomson, R.J., Alymova, I., Portner, A., von itzstein, M. and Taylor, G. (2005) Glycoconjugate J. (in press) Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle Disease Virus

14.Alymova, I.V., Taylor, G. and Portner, A. (2005) Current Drug Targets (in press) Neuraminidase Inhibitors as Antiviral Agents

15.Leonard, VHJ, Kohl, A., McLees, A. and Elliott RM. 2005. Homotypic interactions of the Bunyamwera bunyavirus nucleocapsid protein. Journal of Virology, in press.

16.Barona-Gomez F, Wong U, Giannakopulos A, Derrick PJ, and Challis GL. 'Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145'. (2004) J. Am. Chem. Soc. 126: 16282-16283

17.Challis GL, Naismith, JH. 'Structural aspects of nonribosomal peptide biosynthesis'. (2004) Curr. Op. Struct. Biol. 14: 748-756

18.Challis GL. 'A widely distributed bacterial pathway independent of nonribosomal peptide synthetases for siderophore biosynthesis' (2005) ChemBioChem 6: 601-611

19.Lautru S, Deeth RJ, Bailey LM, Challis GL. 'Discovery of a new peptide natural product by Streptomyces coelicolor genome mining'. (2005) Nature Chem. Biol. 1: 265-269

20.Corre C, Challis GL. 'Evidence for the unusual condensation of a diketide with a pentose sugar in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2)'. (2005) ChemBioChem, accepted for publication - in press

21.Walton LJ, Corre C, Challis GL. 'Mechanisms for the incorporation of glycerol-derived precursors into polyketide metabolites'. (2005) J. Ind. Microbiol. Biotechnol. accepted for publication - in press

22.Alphey, M.S.,Yu, W., Byres, E., Li, D. and Hunter, W.N.Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase; enzyme-ligand interactions in a distinctive short-chain reductase active site. J. Biol. Chem. (2005) 280, 3068-3077.

23.Kemp, L.E., Alphey, M.S., Bond, C.S., Ferguson, M.A.J., Hecht, S., Bacher, A., Eisenreich,W., Rohdich, F., and Hunter, W.N. The identification of isoprenoids that bind in the inter-subunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase. Acta Cryst. (2005) D61, 45-52.

24.Sgraja, T, Kemp, L.E., Ramsden, N. and Hunter, W.N. A double mutation of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate. Acta Cryst. (2005) F61, 625-629.

25.Byres, E., Martin, D.M.A. and Hunter, W.N. A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei. Acta Cryst. (2005) F61, 581-584.

26.S. Cameron, S. McLuskey, K. Chamberlayne, R., Hallyburton, I. and Hunter, W.N. Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis Acta Cryst. (2005) F61, 534-536.

27.McLuskey, K., Cameron, S., Hammerschmidt, F. and Hunter, W.N. Crystal structure and reactivity of hydroxypropylphosphonic acid epoxidase; fosfomycin biosynthesis by a novel cation and flavin-dependant mechanism. Proc. Natl. Acad. Sci. USA. (2005)

28.Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH, Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 2006 Dec;13(12):1069-77. Epub 2006 Nov 12. PubMed

29.Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL, Clarke BR, Whitfield C, Naismith JH. Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein. Nature. 2006 Nov 9;444(7116):226-9. Epub 2006 Nov 1. PubMed

30.McMahon SA, Walsh MA, Ching RT, Carter LG, Dorward M, Johnson KA, Liu H, Oke M, Bloch C Jr, Kennedy MW, Latiff AA, Cooper A, Taylor GL, White MF, Naismith JH. Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1124-6. Epub 2006 Oct 20. PubMed

31.Williams GJ, Johnson K, Rudolf J, McMahon SA, Carter L, Oke M, Liu H, Taylor GL, White MF, Naismith JH. Structure of the heterotrimeric PCNA from Sulfolobus solfataricus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):944-8.Epub 2006 Sep 19. PubMed

32.Overton IM, Barton GJ.A normalised scale for structural genomics target ranking: the OB-Score. FEBS Lett. 2006 Jul 10;580(16):4005-9. Epub 2006 Jun 16. PubMed

33.McEwan AR, Liu H, Oke M, Carter L, Powers H, Dorward M, McMahon SA, White MF, Naismith JH. Overexpression, purification, crystallization and data collection of Sulfolobus solfataricus Sso6206, a novel highly conserved protein. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):228-30.Epub 2006 Feb 10. PubMed

34.Dong C, Flecks S, Unversucht S, Haupt C, van Pee KH, Naismith JH.Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science. 2005 Sep 30;309(5744):2216-9. PubMed

35.Dong C, Kotzsch A, Dorward M, van Pée KH, Naismith JH. Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens. Acta Crystallographica Section D 60 (8), 1438–1440.

36.J. Seetharamappa, M. Oke, H. Liu, S. A. McMahon, K. A. Johnson, L. Carter, M. Dorward, M. Zawadzki, I. M. Overton, C. A. J. van Niekirk, S. Graham, C. H. Botting, G. L. Taylor, M. F. White, G. J. Barton, P. J. Coote and J. H. Naismith. Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase. Acta Cryst. (2007). F63, 452-456 PDF

37.Beverley A. Yard, Lester G. Carter, Kenneth A. Johnson, Ian M. Overton, Mark Dorward, Huanting Liu, Stephen A. McMahon, Muse Oke, Daphné Puech, Geoffrey J. Barton, et al. The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. Journal of Molecular Biology, In Press, Accepted Manuscript, Available online 10 May 2007. PDF