The SSPF is a high-throughput structural genomics project, utilising technologies for cloning, protein expression, purification,crystallisation, structure determination and bioinformatical analysis. All experimental data is stored in our online database (PiMS). We concentrate mainly on proteins from thermostable archea and their viruses, and proteins from pathogenic bacteria such as methicillin resistant staphylococcus aureus (MRSA), clostridium difficile and vibrio cholerae.

The figure below shows the pipline approach we take to solving protein structures, and highlights some of the technologies we use at each stage.