| The structure of AlcC, a type C siderophore synthetase, with a molecular weight of 70,605 Da from Bordetellae, has been determined to 2.4 Å. Crystal symmetry generates a dimer. The fold of the protein is related to AcsD, although the homology is quite low preventing a molecular replacement solution. Mechanistically the adenyl transfer reaction will be related to AcsD, however substrate specificity is quite different. Additionally type C enzymes are often processive, the structure of AlcC will greatly help in our understanding siderophore biosynthesis. It also present a novel target for drug design.
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